Faculty Bio

Overview

Faculty

Administration

Joseph M. Zmuda, PhD

Assistant Professor of Epidemiology & Human Genetics
Department of Epidemiology
A544 Crabtree Hall
University of Pittsburgh
Pittsburgh, PA 15261
Voice: 412-624-2970
E-mail: zmudaj@edc.pitt.edu

Research Interests

• Genetic and molecular epidemiology of common complex diseases
• Osteoporosis
• Prostate cancer
• Aging

Research Support

• Principal Investigator
  • NIH-NIAMS (R03-AR050107) Determinants of Bone Strength in Afro-Caribbean Families.
  • NIH- NIAMS (R01-AR049747) Epidemiology of Bone Loss in African Men.
  • NIH-NIAMS (R01-AR051124) Bone Strength Phenotypes in Men: Genes and Environment.
  • National Osteoporosis Foundation; Genetic Analysis of Wingless-Type (WNT) Pathway and Bone Health in Men.
  • Arthritis Foundation; Genetic Epidemiologic Analysis of the LRP5 Signaling Pathway and Bone Strength in African Men.
  • Interleukin Genetics; Case-Control Study of the Relationship Between Common IL-1 Gene Polymorphisms and the Risk of Vertebral Fracture in Women.
• Co-Investigator
  • NIH-NIAMS R01-AR035582; (J.Cauley-PI); Study of Osteoporotic Fractures.
  • NIH-NIAMS R01-AG021024; (R. Ferrell-PI); Genetic Epidemiology of Musculoskeletal Aging.
  • NIH-NIA; R01-AR048919 (S.Cummings-PI)Women’s Health Initiative Hip Fracture Biomarker Study.

Education & Training

• University of Rhode Island - B.S. Nutrition, 1989
• University of Rhode Island - M.S. Exercise Physiology, 1991
• University of Pittsburgh, Graduate School of Public Health Epidemiology, M.P.H. - 1996, PhD - 2000
• Post-Doctoral Training
  
  • PCR and Molecular Biology Workshop, Smith College, New England Biolabs, 2001
  • University of Pittsburgh Cancer Institute, Cancer Epidemiology, Department of Epidemiology, Pittsburgh, PA, 2001-2003
  • Genetic Analysis of Complex Human Diseases, Duke University Medical Center, Center for Human Genetics, Durham, NC, 2003
  • Short Course in Statistical Genetics, University of Alabama Section on Statistical Genetics, Washington, DC, 2004
  • Genomics and Genetic Epidemiology, Harvard Medical School, Department of Genetics and Center for Genetics and Genomics, Boston, MA, 2004
  • Genomics in Biomedical Research, Programs for Genomic Applications, University of California, Berkeley, CA, 2004.

Awards & Honors

1995-1996	United States Public Health Service Traineeship
1997	National Osteoporosis Foundation Fellowship Award
1997	American Society for Bone and Mineral Research Quantitative Ultrasound Research Award (Finalist)
1998	Judy S. Finkelstein Memorial Award
2000	Outstanding Student Award, Graduate School of Public Health, University of Pittsburgh
2000	Delta Omega National Honor Society
2001	American Federation for Aging Research Award
2003	Young Investigator Award, American Society for Bone and Mineral Research

Selected Publications

Walsh S, Zmuda JM, Cauley JA, Shea PR, Metter EJ, Hurley BF, Ferrell RE, and Roth SM. Androgen Receptor CAG Repeat Polymorphism is Associated with Fat Free Mass in Men. Journal of Applied Physiology 2005; 98(1) 132-7.

Lian K, Zmuda JM, Nevitt MC, Lui L, Hochberg MC, Greene D, Li J, Lane NE Collagen Type IA1 Sp1 Transcription Factor Binding Site Polymorphism is Associated with Reduced Risk of Hip OA Defined by Significant Joint Space Narrowing in Elderly Women. Arthritis and Rheumatism. (In Press)

Moffett SP, Zmuda JM, Cauley JA, Stone K, Nevitt M, Ensrud M, Hillier TA, Hochberg MC, Joslyn G, Morin P, Cummings SR. for the SOF Research Group. The G-174C Variant in the Interleukin 6 Promoter Region Is Associated With Bone Loss and Fracture Risk In Older Women. Journal of Bone and Mineral Research. 2004; 19(10):1612-8

Jacob AC, Zmuda JM, Cauley JA, Metter EJ, Hurley BF, Ferrell RE, Roth SM. Ciliary Neurotrophic Factor (CNTF) Genotype and Body Composition. European Journal of Human Genetics. 2004; 12(5):372-6.

Roth SM, Zmuda JM, Cauley JM, Shea PR, Ferrell RE. Vitamin D Receptor Genotype is Associated with Fat Free Mass and Sarcopenia in Elderly Men. Journal of Gerontology. 2004; 59(1):10-5.

Yaffe K, Edwards ER, Lui LY, Zmuda JM, Ferrell RE, Cauley JA. Androgen Receptor CAG Repeat Polymorphism is Associated with Cognitive Function in Older Men. Biological Psychiatry 2003; 54(9):943-6.

Zmuda JM, Cauley JA, Danielson ME, Ferrell RE. Vitamin D Receptor and Aromatase Gene Interaction and Bone Mass in Older African American Women. Metabolism. 2003; 52(5):521-3.

Modugno F, Weissfeld JL, Trump DL, Zumda JM, Shea P, Cauley JA, Ferrell RE. Allelic variants of aromatase and the androgen and estrogen receptors: towards a multigenic model of prostate cancer risk. Clin Cancer Res 2001;7:3092-96

Zmuda JM, Cauley JA, Ferrell RE. Molecular epidemiology of vitamin D receptor gene variants. Epidemiol Rev 2001;22:203-17

Zmuda JM, Cauley JA, Kuller LH, Ferrell RE. A common promoter variant in the cytochrome P450c17a Gene (CYP17) is associated with bioavailable testosterone levels and bone size in men. J Bone Miner Res 2001;16:911-17

Salamone LM, Cauley JA, Zmuda J, Pasagian-Macaulay A, Epstein RS, Ferrell RE, Kuller LH. Apolipoprotein E gene (APOE) polymorphism and bone loss: estrogen status modifies the influence of APOE on bone loss. J Bone Miner Res 2000;15:308-14

Zmuda JM, Cauley JA, Ferrell RE. Recent progress in understanding the genetic susceptibility to osteoporosis. Genet Epidemiol 1999;16:356-67

Ensrud KE, Stone K, Cauley JA, White C, Zmuda JM, Nguyen TB, Eisman JA, Cummings SR for the Study of Osteoporotic Fractures Research Group. Vitamin D-receptor gene polymorphisms and the risk of fractures in older women. J Bone Miner Res 1999;14:1637-45

Cauley JA, Zmuda JM, Yaffe J, Kuller LH, Ferrell RE, Wisniewski S, Cummings SR. Apolipoprotein E polymorphism: a new genetic marker of hip fracture risk. J Bone Miner Res 1999;14:1175-81

Zmuda JM, Cauley JA, Danielson ME, Theobald TM, Ferrell RE. Vitamin D receptor translation initiation codon polymorphism and markers of osteoporotic risk in older African-American women. Osteoporos Int 1999;9:214-19