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Kim C. Sutton-Tyrrell, DrPH
Professor and Vice Chair for AcademicsDepartment of Epidemiology 505A Parran Hall University of Pittsburgh Pittsburgh,PA 15261 Voice: 412-624 1122 E-mail: tyrrell@edc.pitt.edu Research Interests Dr. Kim Sutton-Tyrrell is Professor and Vice Chair for Academics for the Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh. Her primary scientific area is the application of subclinical measures of atherosclerosis to population studies. To support this area of research, Dr. Tyrrell has founded and now directs the Department of Epidemiology Ultrasound Research Laboratory (URL). This facility provides research quality ultrasound exams for an average of 2,000 study subjects annually. The lab is a shared resource for University Investigators and is supported through grants from institutions such as the National Institutes of Health and the American Heart Association. The lab provides research protocols for numerous subclinical disease measures including carotid intima-media thickness (IMT), arterial stiffness, endothelial function and plaque composition. Much of Dr. Tyrrell's research has focused on the area of women's health. She has collaborated with other University faculty in the evaluation of cohorts at high risk for CVD such as women with lupus, polycystic ovary disease and rheumatoid arthritis. In addition, she has worked with other investigators to evaluate CV risk factors in women transitioning the menopause. Another major area of concentration for Dr. Tyrrell has been the application of quantitative methodology to epidemiological studies and the conduct and coordination of multi-center studies and clinical trials. Through her involvement with the Epidemiology Data Center, Dr. Tyrrell has focused on the coordination, data management and statistical analysis of large multi-center studies with an emphasis on clinical trials. She has developed, implemented and published strategies to manage and monitor large multi-center studies. Dr. Tyrrell is currently the PI of the Coordinating Center for the NIA-funded Study of Women's Health Across the Nation (SWAN). She is also the PI of a clinical trial to evaluate the effect of sodium consumption on vascular health. Dr. Tyrrell's Departmental responsibilities include oversight of the student services office and ongoing development of the Department's curriculum. And faculty support for teaching and mentoring. Research Support
Co Principal Scientific Director Education & Training Selected Publications Sutton KC, Wolfson SK, Kuller L: Carotid and lower extremity arterial disease in adults with isolated systolic hypertension. Stroke, 18:817-822, 1987. Sutton-Tyrrell K: Assessing bias in case-control studies: Proper selection of cases and controls. Stroke 1991;22:938-942. Sutton-Tyrrell K, Wolfson SK and Kuller LH: Treatment of isolated systolic hypertension slows the progression of carotid stenosis. Stroke 1994;25:44-50. Sutton-Tyrrell K, Alcorn HG, Kelsey SF and Kuller LH: Peripheral atherosclerosis and subsequent morbidity and mortality in older adults with isolated systolic hypertension. Stroke 1995;26:1329-1334. Sutton-Tyrrell K, Bostom A, Selhub J and Zeigler-Johnson C. High Homocysteine Levels are Independently Related to Isolated Systolic Hypertension in Older Adults. Circulation 1997;6:1745-1749. Sutton-Tyrrell K, Rihal C, Burek K, Sellers M, Jandova R, Hollak B, Trudel J, Lazzam L, Brooks M, Sopko G. Long-term prognostic value of clinically evident noncoronary vascular disease in patients undergoing Coronary Revascularization in the Bypass Angioplasty Revascularization Investigation. Am J Cardiol. 1998;81:375-381. Sutton-Tyrrell K, Kuller LH, Edmundowicz D, Feldman A, Holubkov R, Givens L, Matthews KA. Progression of coronary and aortic calcification by electron beam tomography in middle-aged women. Am J Cardiol 2001;87:560-564. Sutton-Tyrrell K, Kuller LH, Matthews KA, Holubkov R, Patel A, Edmundowicz D and Newman AB. Subclinical atherosclerosis in multiple vascular beds: an index of atherosclerotic burden evaluated in postmenopausal women. Atherosclerosis 2002:160:407-416 Sutton-Tyrrell K, Matthews K, Kuller LH, Wildman R. Extent of cardiovascular risk reduction associated with treatment of isolated systolic hypertension. Arch Intern Med 2003; 163:2728-2731. Wildman RP, Sutton-Tyrrell K, Newman AB, Bostom A, Brockwell S, Kuller LH. Lipoprotein levels are associated with incident hypertension among older adults. J Am Ger Soc 2004;52:916-921 Sutton-Tyrrell K, Wildman RP, Matthews KA, Chae C, Lasley BL, Brockwell S, Paternak RC, Lloyd-Jones D, Sowers MF, Torréns JI for the SWAN Investigators. Sex hormone-binding globulin and the free androgen index are related to CV risk factors in multi-ethnic pre and peri-menopausal women enrolled in The Study of Women's Health Across the Nation (SWAN). Circulation 2005:111:1242-1249. Mackey RH, Kuller LH, Sutton-Tyrrell K, Evans RW, Holubkov R, Matthews KA. Hormone therapy, lipoprotein subclasses, and coronary calcification: The Healthy Women Study. Arch Intern Med 2005;165:510 Matthews K, Agatisa P, Bromberger J, Chang Y, Tyrrell KS, Edmundowicz D. Coronary and aortic calcification in women with major depression history. Arch Int Med 2005, 65;1-8 Gungor N, Arslanian S, Sutton-Tyrrell K, Thompson T, Janosky JE. Early signs of cardiovascular disease in youth with obesity and Type 2 Diabetes. Diabetes Care 2005; 28(5):1219-1221. Sutton-Tyrrell K, Najjar S, Kupelian V, Simonsick E, Havlik R, Lakatta E, Spurgeon H, Kritchevsky S, Pahor M, Bauer D, Newman A, Venkitachalam L, Boudreau R for Health ABC Study. Elevated aPWV, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults. Circulation 2005,20; 111:3384-90. Lloyd-Jones DM, Sutton-Tyrrell K, Patel AS, Matthews KA, Pasternak RC, Everson-Rose SA, Scuteri A, Chae CU. Ethnic variation in hypertension among permenopausal and perimenopausal women: Study of Women's Health Across the Nation. Hypertension 2005:46(4):689-95. Wildman R, Muntner P, Chen J, Sutton-Tyrrell K, He J. Relation of Inflammation to Peripheral Arterial Disease in the National Health and Nutrition Examination Survey, 1999-2002. Am J Cardiology 2005;96:1579-83. Janicki D, Kamarck T, Shiffman S, Sutton-Tyrrell K, Gwaltney C. Frequency of spousal interaction and 3-year progression of carotid artery intima medial thickness: the Pittsburgh Healthy Heart Project. Psychom Med 2005 67(6):889-96. Bleil ME, Ferrell RE,Sutton-Tyrrell K, Juldoon MF, Manuck SB. Apolipoprotein E polymorphism & preclinical carotid artery disease in untreated hypertensive men. Eur J Cardiovasc Prev Rehabil 2006;13(1):98-100. Matthews KA, Santoro N, Lasley B, chang Y, Crawford S, Pasternak RC, Sutton-Tyrrell K, Sowers MF. Relation of Cardiovascular Risk Factors in Women Approaching Menopause to Menstrual Cycle Characteristics and Reproductive Hormones in the Follicular and Luteal Phases. J Clin Endocrinol Metab 2006; 91(5):1789-1795. Bleil ME, Ferrell RE, Sutton-Tyrrell K, Juldoon MF, Manuck SB Apolipoprotein E polymorphism and preclinical carotid artery disease in untreated hypertensive men. Eur J Cardiovasc Prev Rehabil 2006;13(1):98-100. Peterson K, Bleil M, McCaffery J, Mackey R, Sutton-Tyrrell K, Muldoon M, Manuck S. Community socio-economic status is associated with carotid artery atherosclerosis in untreated, hypertensive men. Am J Hypertens 2006 Jun;19(6):560-6. Lewis TT, Everson-Rose SA, Powell LH, Matthews KA, Brown C, Karavolos K, Sutton-Tyrrell K, Jacobs E, Wesley D. Chronic exposure to everyday discrimination and coronary artery calcification in African-American women: the SWAN Heart Study. Psychosom Med 2006;May-Jun;68(3):362-8. Farhat G, Strotmeyer E, Newman A, Tyrrell KS, Bauer D, Harris, Johnson K, Cauley J. Volumetric and A real Bone Mineral Density Measures Are Associated with Cardiovascular Disease in Older Men and Women: The Health Aging and Body Composition Study (Health ABC). Calcified Tissue Intern, 2006. Catov JM, Newman AB, Roberts JM, Sutton-Tyrell KC, Kelsey SF, Harris T, Jackson R, Colbert LH, Satterfield S, Ayonayon HN, Ness RB. Association between infant birth weight and maternal cardiovascular risk factors in the Health, Aging and Body Composition Study. Ann Epidemiol 2006 Jul 11 [Epub ahead of print]. Farhat G, Cauley J, Matthews K, Newman A, Johston J, Mackey R, Edmundowicz, Sutton-Tyrrell K. Volumetric Bone Mineral Density and Vascular Calcification in Middle-Aged Women: the Study of Women's Health Across the Nation" J Bone Mineral Res, 2006;21(12):1839-1846. Johnston JM, Colvin A, Johnson D, Santoro N, Harlow SD, Merz CNB, Sutton-Tyrrell K. Comparison of SWAN and WISE Menopausal Status Classification Algorithms. J Women's Health 2006;15(10):1184-1194. Barinas-Mitchell E, Kuller LH, Sutton-Tyrrell K, Hegazi R, Harper P, Mancino J, Kelley DE. Effect of weight loss and nutritional intervention on arterial stiffness in type 2 diabetes. Diabetes Care 2006;29(10):2218-22. Kuller LH, Kriska AM, Kinzel LS, Simkin-Silverman LR, Sutton-Tyrrell K, Johnson B, Conroy M. The clinical trial of Women on the Move through Activity and Nutrition (WOMAN) Study. Contemp Clin Trials 2007:28(4):370-381 Mackey RH, Venkitachalam L, Sutton-Tyrrell K. Calcifications, arterial stiffness and atherosclerosis. Adv Cardiol 2007:44:234-44. Catov JM, Newman AB, Roberts JM, Sutton-Tyrrell KC, Kelsey SF, Harris T, Jackson R, Colbert LH, Satterfield S, Ayonayon HN, Ness RB. Associaiton between infant birth weight and maternal cardiovascular risk factors in the Health, Aging, and Body Composition Study. Ann Epidemiol 2007;17:36-43. Stewart JC, Janicki DL, Muldoon MF Sutton-Tyrrell K, Kamarck TW. Negative emotions and 3-year progressionof subclinical atherosclerosis. Arch Gen Psychiatry 2007;64:2225-233. Sekikawa A, Hueshima, Kadowaki, Amest, Tokamura, Oomph, Kasiwagi, Edmundowicz D, Murata, Tyrrell KS, Maegawa, Evans R, Kita, Kuller L. Less subclinical atherosclerosis in Japanese men in Japan than in white men in the United States in the post World War II birth cohort. Am J Epidemiology 2007;165(6):617-24. Gautier C, Stine L, Jennings JR, Sutton-Tyrrell K, Muldoon M, Kamarck T, Kaplan GA, Salonen J, Manuck S. Reduced low frequency heart rate variability relates to greater intimal-medial thickness of the carotid wall in two samples. Coron Art Dis 2007;18(2):97-104. Farhat G, Newman A, Tyrrell KS, Matthews K, Boudreau R, Schwartz A, Harris T, Lavsky FT, Visser M, Cauley J. The association of bone mineral density measures with incident cardiovascular disease in older adults. Osteoporosis Intern 2007;18(7):999-1008.. Santoro N, Brockwell S, Johnston J, Crawford SL, Gold EB, Harlow, Matthews KA, Sutton-Tyrrell K. Doctor, When Are My Periods Going to End?" Helping Midlife Women Predict the Onset of the Final Menses? SWAN, the Study of Women's Health Across the Nation' Menopause 2007; 14(3);415-24 Venkitachalam L, Mackey RH,Sutton-Tyrrell K, Patel AS, Boraz MA, Simkin-Silverman Lr, Kuller. Elevated pulse wave velocity increases the odds of coronary calcium in overweight postmenopausal women. Am J Hypertens 2007; 20(5):469-75. Kamarck TW, Muldoon MF, Shiffman SS, Sutton-Tyrrell K. Experiences of demand and control during daily life are predictors of carotid atherosclerotic progression among health men. Health Psychology 2007;26(3):324-32. Nakamura Y, Ueno Y, Tamaki S, Kadowaki T, Okamura T, Kita Y, Miyamatsu N, Sekikawa A, Takamiya T, El-Saed A, Sutton-Tyrrell K, Ueshima. Fish consumption & early atherosclerosis in middle-aged men. Metabolism 2007;56:1060-1064. Muldoon M, Mackey RH, Sutton-Tyrrell K, Flory JD, Pollock BG, Manuck S. Lower central serotonergic responsivity is associated with preclinical carotid artery atherosclerosis. Stroke 2007;38:2228-2233. El-Saed A, Sekikawa A, Edmundowicz D, Evans R, Tyrrell KS, Kadowaki T, Choo J, Takamiya T, Kuller L. Coronary Calcification is More Predictive of Carotid Intimal Medial Thickness in Black Compared to White Middle Aged Men. Atherosclerosis 2008;March 8 196:913-18. Sutton-Tyrrell, K, Venkitachalam L, Kanaya A, Boudreau R, Harris T, Thompson T, Mackey R, Visser M, Vaidean G, Newman AB, for the Health ABC Study. Relationship of high and low ankle blood pressures to mortality and cardiovascular events in well-functioning older adults. Stroke 2008;39:863-869. El-Saed A, Sekikawa A, Edmundowicz D, Evans RW,Sutton-Tyrrell K, Kadowaki T, Choo J, Takamiya T, Kuller LH. Coronary calcification is more predictive of crotid intimal medial thickness in black compared to white middle aged men. Atherosclerosis 2008;196:913-918. Sekikawa A, Ueshima H, Sutton-Tyrrell K, Kadowaki T, El-Saed A, Okamura T, Takamiya T, Ueno Y, Evans RW, Nakamura Y, Edmundowicz D, Kashiwagi A, Maegawa H, Kuller LH. Intima-media thickness of the carotid artery and the distribution of lipprotein subclasses in men aged 40-49 years between whites in the United Staets and the Japanese inJapan for the ERA JUMP Study. Metabolism Clin Exper 2008;57:177-182. Newman AB, Naydeck BL, Ives DG, Boudreau RM,Sutton-Tyrrell K, OLeary DH, Kuller LH. Coronary artery calcium, carotid artery wall thickness and cardiovascular disease outcomes in adults 70 to 99 years old. Am J Cardiol 2008;101:186-192. Thompson T, Sutton-Tyrrell K, Wildman RP, Kao A, Fitzgerald SG, Shook B, Tracy RP, Kuller LH, Brockwell S, Manzi S. Progression of carotid intima-media thickness and plaque in women with systemic lupus erythematosus. Arthritis Rheum. 2008 Feb 29;58(3):835-842 Brach JS, Solomon C, Naydeck BL, Sutton-Tyrrell K, Enright PL, Jenny NS, Chaves PM, Newman AB, for the Cardiovascular Health Study Research Group. Incident Physical Disability in People with Lower Extremity Peripheral Arterial Disease: The Role of Cardiovascular Disease. J Am Geriatrics Soc. 2008 Apr 1 [Epub ahead of print] Choo J, Ueshima H, Jang Y, Sutton-Tyrrell K, El-Saed A, Kadowaki T, Tkakmiya T, Okamura T, Ueno Y, Nakamura Y, Sekikawa A, Curb D, Kuller LH, Shin C. Difference in carotid intima-media thickness between Korean and Japanese Men. Ann Epidemiol 2008; April 18(4):310-5. Yeboah J, Sutton-Tyrrell K, McBurnie MA, Burke GL, Herrington DM, Crouse. Association between brachial artery reactivity and cardiovascular disease status in an elderly cohort: The Cardiovascular Health Study. Atherosclerosis 2008; Apr 197(2):768-76. |
