University of Pittsburgh Department of Epidemiology
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University of Pittsburgh Department of Epidemiology
About
Faculty Bio

Anne B. Newman, M.D., M.P.H.

Professor of Epidemiology and Medicine
Director, Center for Aging and Population Health
Department of Epidemiology
University of Pittsburgh
130 N. Bellefield Avenue, Room 531
Pittsburgh, PA 15213
Voice: 412-383-1871
http://www.caph.pitt.edu
E-mail: newmana@edc.pitt.edu





Research interests
  • Cardiovascular Disease Epidemiology
  • Subclinical atherosclerosis: Associations with aging, disability and frailty
  • Sarcopenia and disability
  • Sleep, Aging, and Chronic Illness, Sleep Apnea and Aging
Research Support
  • Principal Investigator
    • The Sleep Heart Health Study (2004-2008) NHLBI
    • Families of cohort survivors over 90 – Study Center (2004-2009) NIA
    • Exceptional aging: 12 year trajectories to function (2004-2008) NIA
    • Physical Exercise to Prevent Disability Pilot Study (2003-2009) WFU/NIA
    • Lifestyle Intervention and Independence for Elders (2005-2009) UF/NIA
    • The Health, Aging and Body Composition Study (1996-2008) NIA
  • Co-Principal Investigator
    • University of Pittsburgh Clinical Center for the Osteoarthritis Institute (2002-2009) NIAMS
    • Center for Healthy Aging (2001-2009) CDC
    • Cardiovascular Health Study (CHS) 1988-2006) NHLBI
    • Peripheral Nerve Function Decline in an Aged Cohort (2007-2011)
    • Brain Anatomical Correlates of Mobility Control in Oldest Old (2007-2012)
  • Other
    • Pittsburgh Older Americans Independence Center (Core Director) (2004-2009) NIA
    • Training in the Epidemiology of Aging (Director) (2008-2010) NIH/NIA
Education and Training
  • University of Pittsburgh – B.S. Biology, 1978
  • University of Pittsburgh – M.D. Medicine, 1982
  • University of Pittsburgh – M.P.H. Public Health, 1987
  • Presbyterian University Hospital – Internship & Residency, 1982-1985
  • Presbyterian University Hospital – Fellowship Geriatric Medicine, 1985-1987
Selected Publications
  1. Keller CR, Odden MC, Fried LF, Newman AB, Angleman S, Green CA, Cummings SR, Harris TB, Shlipak MG. Kidney Function and Markers of Inflammation in Elderly Persons without Chronic Kidney Disease: The Health, Aging and Body Composition Study. Kidney Int. 2007;71:239-244.
  2. LIFE Study Investigators; Pahor M, Blair SN, Espeland M, Fielding R, Gill TM, Guralnik JM, Hadley EC, King AC, Kritchevsky SB, Maralsi C, Miller ME, Newman AB, Rejeski WJ, Romashkan S, Studenski S. Effects of a Physical Activity Intervention on Measures of Physical Performance: Results of the Lifestyle Interventions and Independence For Elders Pilot (LIFE-P) Study. J Gerontol A. Biol Sci Med Sci. 2006;61A:M1157-M1165.
  3. Goodpaster BH, Park SW, Harris TB, Kritchevsky SB, Nevitt M, Schwartz AV, Simonsick EM, Tylavsky FA, Visser M, Newman AB. The Loss of Skeletal Muscle Strength, Mass, and Quality in Older Adults: The Health, Aging and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2006;61A:M1059-M1064.
  4. Manini TM, Visser M, Park SW, Patel KV, Strotmeyer ES, Chen H, Goodpaster B, de Rekeneire N, Newman AB, Simonsick EM, Kritchevsky SB, Ryder K, Schwartz AV, Harris TB, The Health Aging and Body Composition Study. Knee Extension Strength Cutpoints for Maintaining Mobility. J Am Geriatr Soc. 2007;55:451-457.
  5. Park SW, Goodpaster B, Strotmeyer E, Kuller L, Boudreau R, Kammerer C, de Rekeneire N, Harris T, Schwartz A, Tylavsky F, Cho Y-w, Newman AB. Accelerated Loss of Skeletal Muscle Strength in Older Adults with Type 2 Diabetes: The Health, Aging and Body Compostion Study. Diabetes Care. 2007;30:1507-1512.
  6. Espeland MA, Gill TM, Guralnik J, Miller ME, Fielding R, Newman AB, Pahor M, the Lifestyle Interventions and Independence for Elders Study Group. Designing Clinical Trials of Interventions for Mobility Disabilty: Results from the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) Trial. J Gerontol A Biol Sci Med Sci. 2007;62A:M1237-M1243.
  7. Li R, Nicklas B, Newman A, Sutton-Tyrrell K, Harris T, Lakatta E, Bauer DC, Ding J, Satterfield S, Kritchevsky SB. Polymorphisms of Angiotensinogen and Angiotensin-Converting Enzyme Associated with Lower Extremity Arterial Disease in the Health, Aging and Body Composition Study. J Hum Hypertens. 2007;21:673-862.
  8. Irie F, Fitzpatrick AL, Lopez OL, Kuller LH, Peila R, Newman AB, Launer LJ. Enhanced Risk for AD in Type 2 Diabetes with APOE e4: The Cardiovascular Health Cognition Study. Arch Neurol. 2008;168:147-153.
  9. Lee JS, Kritchevsky SB, Tylavsky F, Harris TB, Ayonayon HN, Newman AB, the Health ABC Study. Factors Associated with Impaired Appetitie in Well-Functioning Community-Dwelling Older Adults. J Nutr Eldr. 2007;26:27-43.
  10. Koster A, Pennink BWJH, Newman AB, Visser M, van Gool CH, Harris TB, van Eijk JTM, Kempen GIJM, Brach JS, Simonsick EM, Houston DK, Tylavsky FA, Rubin SM, Kritchevsky SB, the Health ABC Study. Lifestyle Factors and Incident Mobility Limitation in Obese and Non-Obese Older Adults. Obesity. 2007;15:3122-3132.
  11. Cauley JA, Danielson ME, Boudreau RM, Forrest KYZ, Zmuda JM, Pahor M, Tylavsky FA, Cummings SR, Harris TB, Newman AB. Inflammatory Markers and Incident Fracture Risk in Older Men and Women: The Health Aging and Body Composition Study. J Bone Miner Res. 2007;22:1088-1095.
  12. Diehr P, Derleth A, Cai L, Newman AB. The Effect of Different Public Health Interventions on Longevity, Morbidity and Years of Healthy Life. BMC Public Health. 2007;7:52.
  13. Diehr P, Derleth A, Newman AB, Cai L. The Number of Sick Persons in a Cohort. Res Aging. 2007;29:555-575.
  14. Rosano C, Aizenstein HJ, Wu M, Newman AB, Becker JT, Lopez OL, Kuller LH. Focal Atrophy and Cerebrovascular Disease Increase Dementia Risk among Cognitively Normal Older Adults. J Neuroimaging. 2007;17(2):148-155.
  15. Faulkner KA, Redfern MS, Cauley JA, Landsittel DP, Studenski SA, Rosano C, Simonsick EM, Harris TB, Shorr RI, Ayonayon HN, Newman AB, for the Health, Aging, and Body Composition Study. Multitasking: Association between Poorer Performance and a History of Recurrent Falls. J Am Geriatr Soc. 2007;55(4):570-576.
  16. Sarnak MJ, Katz R, Fried LF, Siscovick D, Kestenbaum B, Seliger S, Rifkin D, Tracy R, Newman AB, Shlipak MG, for the Cardiovascular Health Study. Cystatin C and Aging Success. Arch Intern Med. 2008;168:147-153.
  17. Sudore RL, Yaffe K, Satterfield S, Harris TB, Mehta KM, Simonsick EM, Newman AB, Rosano C, Rooks R, Rubin SM, Ayonayon HN, Schillinger D. Limited Literacy and Mortality in the Elderly: the Health, Aging and Body Composition Study. J Gen Intern Med. 2006;21:806-812.
  18. Goldman SE, Stone KL, Ancoli-Israel S, Blackwell T, Ewing SK, Robert Boudreau R, Cauley JA, Hall M, Matthews KA, Newman AB. Poor Sleep is Associated with Poorer Physical Performance and Greater Functional Limitations in Older Women. Sleep. 2007;30:1317-1324.
  19. Catov JM, Newman AB, Roberts JM, Kelsey SF, Sutton-Tyrrell K, Harris TB, Colbert L, Rubin SM, Satterfield S, Ness RB. Preterm delivery and remote maternal cardiovascular disease risk. Epidemiology. 2007;18:733-739.
  20. Fried LF, Boudreau R, Lee JS, Chertow G, Kurella M, Shlipak MG, Ding J, Sellmeyer D, Tylavsky FA, Simsonick E, Kritchevsky SB, Harris TB, Newman AB. Kidney Function as a Predictor of Loss of Lean Mass in Older Adults: Health, Aging and Body Composition Study. J Am Geriatr Soc. 2007;55:1578-1584.
  21. Yaffe K, Kanaya AM, Lindquist K, Hsueh WC, Cummings SR, Beamer B, Newman A, Rosano C, Li R, Harris T. PPAR-? Pro12Ala Genotype and Risk of Cognitive Decline in elders. Neurobiol Aging. 2008;29:78-83.
  22. Yende S, Angus DC, Ding J, Newman AB, Li R, Zmuda J, Kritchevsky SB, Harris TB, Garcia M, Yaffe K, Wunderink RG, for the Health ABC Study. 4G/5G Plasminogen Activator Inhibitor-1 Polymorphisms and Haplotypes are Associated with Pneumonia. Am J Resp Crit Care Med. 2007;176:1129-1137.
  23. Chonchol M, Shlipak MG, Katz R, Sarnak MJ, Newman AB, Siscovick DS, Kestenbaum B, Carney JK, Fried LF. Relationship of Uric Acid with Progression of Kidney Disease. Am J Kidney Dis. 2007;50:239-247.
  24. Morsink LF, Vogelzangs N, Nicklas BJ, Beekman AT, Satterfield S, Rubin SM, Yaffe K, Simonsick E, Newman AB, Kritchevsky SB, Penninx BW; for the Health ABC study. Associations Between Sex Steroid Hormone Levels and Depressive Symptoms in Elderly Men and Women: Results from the Health ABC Study. Psychoneuroendocrinology. 2007;32:874-883.
  25. Brach JS, Studenski S, Perera S, Vanswearingen JM, Newman AB. Stance Time and Step width Variability have Unique Contributing Impairments in Older Persons. Gait Posture. 2008;431-439.
  26. Newman AB, Naydeck BL, Ives DG, Boudreau RM, Sutton-Tyrrell K, O'Leary DH, Kuller LH. Coronary Artery Calcium, Carotid Artery Wall Thickness and Cardiovascular Disease Outcomes in Adults 70 to 99 Years Old. American Journal of Cardiology. 2008;101(2):186-192.
  27. Schaap LA, Pluijm SMF, Deef DJH, Penninx BW, Nicklas BJ, Harris TB, Newman AB, Kritchevsky SB, Cauley JA, Goodpaster BH, Tylavsky FA, Yaffe K, Visser M, for the Health ABC Study. Low Testosterone Levels and Decline in Physical Performance and Muscle Strength in Older Men: Findings from Two Prospective Cohort Studies. Clin Endocrinol. 2008;60:42-50.
  28. Kestenbaum B, Rudser KD, Shlipak MG, Fried LF, Newman AB, Katz R, Sarnak MJ, Seliger S, Stehman-Breen C, Prineas R, Siscovick DS. Kidney Function, Electrocardiographic Findings, and Cardiovascular Events among Older Adults. Clin J Am Soc Nephrol. 2007;2:501-508.
  29. Inzitari M, Newman AB, Yaffe K, Boudreau R, de Rekeneire N, Schorr R, Harris TB, Rosano C, for the Health, ABC Study. Gait Speed Predicts Decline in Attention and Psychomotor Speed in Older Adults: the Health, Aging and Body Composition Study. Neuroepidemiol. 2007;29:156-162.
  30. Hunter DJ, Zhang YQ, Niu JB, Felson DT, Kwoh K, Newman A, Kritchevsky S, Harris T, Carbone L, Nevitt M. Patella Malalignment, Pain and Patellofemoral Progression: the Health ABC Study. Osteoarthritis Cartilage. 2007;15:1120-1127.
  31. Cauley JA, Danielson ME, Boudreau RM, Forrest KY, Zmuda JM, Pahor M, Tylavsky FA, Cummings SR, Harris TB, Newman AB; for the Health ABC Study. Inflammatory Markers and Incident Fracture Risk in Older Men and Women: The Health Aging and Body Composition Study. J Bone Miner Res. 2007;22(7):1088-1095.
  32. Atkinson HH, Rosano C, Simonsick EM, Williamson JD, Davis C, Ambrosius WT, Rapp SR, Cesari M, Newman AB, Harris TB, Rubin SM, Yaffe K, Satterfield S, Kritchevsky SB; Health ABC study. Cognitive Function, Gait Speed Decline, and Comorbidities: The Health, Aging and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2007;62:M844-M850.
  33. Newman AB, Boudreau RM, Naydeck BL, Fried LF, Harris TB. A Physiologic Index of Comorbidity - Relationship to Mortality and Disability. J Gerontol A Biol Sci Med Sci. 2007. In Press.
  34. Hindorff LA, Rice KM, Lange LA, Diehr P, Halder I, Walston J, Kwok P, Ziv E, Nievergelt C, Cummings SR, Newman AB, Tracy RP, Psaty BM, Reiner AP. Common Variants in the CRP Gene in Relation to Longevity and Cause-Specific Mortality in Older Adults: The Cardiovascular Health Study. Atherosclerosis. 2008;197:922-930.
  35. Diehr P, Yanez D, Derleth A, Newman AB. Age-Specific Prevalence and Years of Healthy Life in a System with Three Health States. Stat Med. 2007. In Press.
  36. Mukamal KJ, Kennedy M, Cushman M, Kuller LH, Newman AB, Pollak J, Criqui MH, Siscovick DS. Alcohol Consumption and Low Extremity Arterial Disease Among Older Adults: The Cardiovascular Health Study. Am J Epidemiol. 2008; 167: 34 - 41.
  37. Rajpathak SN, McGinn AP, Strickler HD, Rohan TE, Pollak M, Cappola AR, Kuller L, Xue X, Newman AB, Strotmeyer ES, Psaty BM, Kaplan RC.Insulin-Like Growth Factor-(IGF)-Axis, Inflammation, and Glucose Intolerance Among Older Adults. Growth Horm IGF Res. 2007. In Press.
  38. Rosano C, Brach J, Studenski S, Longstreth WT Jr, Newman AB. Gait Variability is Associated with Subclinical Brain Vascular Abnormalities in High-Functioning Older Adults. Neuroepidemiology. 2007;29:193-200.
  39. Rodondi N, Newman AB, Cappola AR, Bauer DC. Association Between Subclinical Hypothyroidism and Coronary Heart Disease in 2006. Int J Cardiol. 2007. In Press.
  40. Diehr P, O’Meara ES, Fitzpatrick A, Newman AB, Kuller LH, Burke G. Weight, Mortality, Years of Healthy Life, and Active Life Expectancy in Older Adults. J Am Geriatr Soc. 2008;56:76–83.
  41. Koster A, Patel Kvan Eijk JThM, Kanaya AM, de Rekeneire N, Newman AB, Tylavsky FA, Kritchevsky SB, Harris TB, for the Health ABC Study. Joint Effects of Adiposity and Physical Activity on Incident Mobility Limitation in Older Adults. J Am Geriatr Soc. 2007. In Press.
  42. Kaplan RC, McGinn AP, Pollack MN, Kuller L, Strickler HD, Rohan T, Xue S, Kritchevsky SB, Newman AB, Psaty B. Total IGF-I and IGFBP Levels, Functional Status, and Mortality Among Older Adults. J Am Geriatr Soc. 2007. In Press.
  43. Church TS, Gill TM, Newman AB, Blair SN, Earnest C, Pahor M. Maximal Fitness Testing in Sedentary Elderly at Substantial Risk of Disability: Experience for the LIFE Study. J Aging Phys Act. 2007; In Press.
  44. Mittalhenkle A, Stehman-Breen CO, Shlipak MG, Fried LF, Katz R, Young BA, Seliger S, Gillen D, Newman AB, Psaty BA, Siscovick D. Cardiovascular Risk Factors and Incident Acute Renal Failure in Older Adults: The Cardiovascular Health Study. Clin J Am Soc Nephrol. 2008;3:450-456.
  45. Deo R, Fyr CL, Fried LF, Newman AB, Harris TB, Angleman S, Green C, Kritchevsky SB, Chertow GM, Cummings SR, Shlipak MG; Health ABC study. Kidney dysfunction and fatal cardiovascular disease--an association independent of atherosclerotic events: results from the Health, Aging, and Body Composition (Health ABC) study. Am Heart J. 2008;155:62-68.
  46. Houston DK, Nicklas BJ, Ding J, Harris TB, Tylavsky FA, Newman AB, Lee JS, Sahyoun NR, Visser M, Kritchevsky SB, for the Health ABC Study. Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the Health, Aging, and Body Composition (Health ABC) Study. Am J Clin Nutr. 2008;87:150-155.
  47. Lemster BH, Michel JJ, Montag DT, Paat JJ, Studenski SA, Newman AB, Vallejo AN. Induction of CD56 and TCR-Independent Activation of T Cells with Aging. J Immunol. 2008;180:1979-1990.
  48. Patel KV, Harris TB, Newman AB, Guralnik JM. Further epidemiologic research on anemia in older adults is needed. Response to: Artz and Dong “Defining Anemia by Race Using Epidemiologic Data”. Blood. 2008;111:2941-2942.
  49. Freiberg MS, Arnold AM, Newman AB, Edwards MS, Kraemer KL, Kuller LH. Abdominal Aortic Aneurysms, Increasing Infrarenal Aortic Diameter, and Risk of Total Mortality and Incident Cardiovascular Disease Events: 10-year Follow-up Data from the Cardiovascular Health Study. Circulation. 2008;117:1010-1017.
  50. Sutton-Tyrrell K, Venkitachalam L, Kanaya AM, Boudreau R, Harris T, Thompson T, Mackey RH, Visser M, Vaidean GD, Newman AB. Relationship of Ankle Blood Pressures to Cardiovascular Events in Older Adults. Stroke. 2008;39:863-869.
  51. Picarsic JL, Glynn NW, Taylor CA, Katula J, Goldman SE, Studenski S, Newman AB. Self-reported Napping, Sleep Duration and Quality in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) Study. J Am Geriatr Soc. 2008. In Press.
  52. Brach J, Talkowski J, Strotmeyer ES, Newman AB. Diabetes Mellitus and Gait Dysfunction: Possible Explanatory Factors. Phys Ther. 2008. In Press.
  53. Melzer D, Perry JRB, Hernandez D, Corsi A, Stevens K, Raffety I, Lauretani F, Murray A, Gibbs JR, Paolisso G, Rafiq S, Simon-Sanchez J, Lango H, Scholz S, Weedon MN, Arepalli S, Rice N, Washecka N, Hurst A, Britton A, Henley W, van de Leemput J, Li R, Newman AB, Tranah G, Harris TB, Paniker V, Dayan C, Bennet A, McCarthy M, Jarvelin MR, Guralnik JM, Bandinelli S, Frayling TM, Singleton A, Ferrucci L. A genome wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genetics. 2008. In Press.
  54. Goldman SE, Hall M, Boudreau R, Matthews KA, Cauley JA, Ancoli-Israel S, Stone KL, Rubin SM, Satterfield S, Simonsick EM, Newman AB. Association between nighttime sleep and napping in older adults. Sleep. 2008;31(5):733-740.
  55. Goldman SE, Ancoli-Israel S, Boudreau R, Hall M, Cauley JA, Stone K, Harris T, Satterfield S, Newman AB. Sleep problems and associated daytime fatigue in community dwelling older individuals. J Gerontol A Biol Sci Med Sci. 2008. In Press.
  56. Brach JS, Kriska A, Glynn N, Newman AB. The Risks and Benefits of Physical Activity in Older Adults. Curr Cardiol Rep. 2008. In Press.
  57. Inzitari M, Naydeck BL, Newman AB. Coronary Artery Calcium and Physical Function in Older Adults: the Cardiovascular Health Study. J Gerontol A Biol Sci Med Sci. 2008. In Press.
  58. Punjabi NM, Newman A, Young T, Resnick E, Sanders M. Sleep-disordered Breathing and Cardiovascular Disease: An Outcome-based Definition of Hypopneas. Am J Respir Crit Care Med. 2008. In Press.
  59. Rooks RN, Simonsick EM, Klesges LM, Newman AB, Ayonayon H, Harris TB. Racial Disparities in Health Care Access and Cardiovascular Disease Indicators in Black and White Older Adults in the Health ABC Study. J Aging Health. 2008. In Press.
  60. Unruh ML, Sanders MH, Redline S, Piraino BM, Umans JG, Chami H, Budhiraja R, Punjabi NM, Buysse D, Newman AB. Subjective and Objective Sleep Quality in Patients on Conventional Thrice-Weekly Hemodialysis: Comparison with Matched Controls from the Sleep Heart Health Study. Am J Kidney Dis. 2008. In Press.
  61. Rifkin DE, Shlipak MG, Katz R, Fried LF, Siscovick D, Chonchol M, Newman AB, Sarnak MJ.Rapid Kidney Function Decline and Mortality Risk in Older Adults. Arch Intern Med. 2008. In Press.
University of Pittsburgh Department of Epidemiology