Assistant Professor of Epidemiology
Graduate School of Public Health
University of Pittsburgh
(412)624-5948
fax: (412)383-5891
Email: mackey@edc.pitt.edu




Research Interests

• Epidemiology of cardiovascular disease, obesity and their interrelationship, including metabolic factors such as adipocytokines, lipoproteins and their subclasses
  
  
• Role of subclinical atherosclerosis, particularly arterial stiffness, in cardiovascular disease and aging
  
  
• Women's Health
  
  
• Advanced analytic methods and study design, particularly longitudinal and case-cohort analysis
  
  

Research Support

Principal Investigator


• Biochemical heterogeneity in morbidly obese women in the WHI- OS. NHLBI R01 HL083326-01, 2006 to present


Co-Investigator


• Evaluation of Specific Markers of Rheumatoid Arthritis, Inflammation, Thrombogenesis, and Risk of Cardiovascular Disease and Total Mortality- WHI BAA #20, PI: L. Moreland



• Hormone Therapy, Estrogen Metabolism and Risk of Beast Cancer or Hip Fracture in the WHI Hormone Trial (2007-09) NHLBI
  
  
• Study of Women's Health Across the Nation III/Coordinating Center (2004-09) NIA

Education & Training

• Princeton University, A.B. Social History, 1990
  
  
• University of Pittsburgh, MPH, Epidemiology 1998
  
  
• University of Pittsburgh, PhD, Epidemiology 2001



• Genomics and Proteomic Approaches to Complex Heart, Lung, Blood & Sleep Disorders
  NHLBI Short Course, Jackson Lab, Bar Harbor, ME, 2008

Selected Publications

Mackey RH, Sutton-Tyrrell K, Vaitkevicius PV, Sakkinen PA, Lyles MF, Spurgeon HA, Lakatta EG, Kuller LH: Correlates of aortic stiffness in elderly individuals: a subgroup of the Cardiovascular Health Study. Am J Hypertens 2002;15:16-23.

Mackey RH, Kuller LH, Sutton-Tyrrell K, Evans RW, Holubkov R, Matthews KA: Lipoprotein subclasses and coronary calcification in postmenopausal women from the Healthy Women Study. Am J Cardiol 2002;90(8suppl):71i-76i.

Wildman RP, Mackey RH, Bostom A, Thompson T, Sutton-Tyrrell K: Measures of obesity are associated with vascular stiffness in young and older adults. Hypertension 2003; 42:468-473.

Muldoon MF, Mackey RH, Williams KV, Korytkowski MT, Flory JD, Manuck SB: Low central nervous system serotonergic responsivity is associated with the metabolic syndrome and physical inactivity. J Clin Endo Metab 2004; 89(1):266-271.

Mackey RH, Kuller LH, Sutton-Tyrrell K, Evans RW, Holubkov R, Matthews KA: Hormone therapy, lipoprotein subclasses and coronary artery calcification: the Healthy Women Study. Arch Int Med. 2005;165:510-515.

Wildman RP, Farhat GN, Patel AS, Mackey RH, Brockwell S, Thompson T, Sutton-Tyrrell K. Weight change is associated with change in arterial stiffness among healthy young adults. Hypertension. 2005;45:187-192.

Muldoon MF, Mackey RH, Korytkowski MT, Flory JD, Pollock BG, Manuck SB: The metabolic syndrome is associated with reduced central nervous system serotonergic responsivity in healthy community volunteers. J Clin Endo Metab. 2006. 91(2):718-721.

Muldoon MF, Mackey RH, Sutton-Tyrrell K, Flory JD, Pollock BG, Manuck SB: Lower central serotonergic responsivity is associated with preclinical carotid artery atherosclerosis. Stroke. 2007;38:2228-2233.

Venkitachalam V, Mackey RH, Sutton-Tyrrell K, Patel AS, Boraz MA, Simkin-Silverman LR, Kuller LH. Elevated pulse wave velocity increases the odds of coronary calcification in overweight postmenopausal women. Am J Hypertens. 2007; 20(5):469-75.

Mukamal KJ, Mackey RH, Kuller LH, Tracy RP, Kronmal RA, Mittleman MA, Siscovick DS. Alcohol consumption and lipoprotein subclasses in older adults. J Clin Endo Metab. 2007. 92(7):2559-2566.

Mackey RH, Venkitachalam L, Sutton-Tyrrell K. "Calcifications, arterial stiffness and atherosclerosis" in: Advances in Cardiology: Atherosclerosis, Large Arteries and Cardiovascular Risk. Ed. ME Safar and ED Frohlich. S. Karger AG, Basel. Vol 44:234-44, 2007.

Sutton-Tyrrell K, Venkitachalam L, Kanaya AM, Boudreau R, Harris T, Thompson T, Mackey RH, Visser M, Vaidean GD, Newman AB. Relationship of ankle blood pressures to cardiovascular events in older adults. Stroke. 2008; 39(3):863-869.

Mackey RH, "Invited Commentary - Weighing benefits for older runners." Arch Int Med 2008 Oct 13;168(18):1948-9