Distinguished University Professor of Public Health
Department of Epidemiology
130 N. Bellefield Avenue, Room 550
Pittsburgh, PA 15213
Voice: (412) 383-1895
E-mail: kullerl@edc.pitt.edu

Research Interests

Epidemiology of CVD
Epidemiology of breast cancer
Epidemiology of aging
HIV and chronic diseases
Dementia
Preventive medicine
Rheumatoid arthritis and CVD

Research Support

Principal Investigator - Active


• Epidemiology of Cardiovascular Risk Factors in Women (1983-2012) NHLBI
• Cardiovascular Health Study Events Follow Up (2005-2010) University of Washington
• Clinical Trial/Observational Study of the Women's Health Initiative (WHI) (2005-2010) NHLBI
• Hormone Therapy, Estrogen Metabolism and Risk in the WHI (2007-2009) NHLBI
• Reduction of Triglycerides in Women on Hormone Therapy (2007-2009)
• Ginkgo Biloba Prevention Trial in Older Adults (2005-2010)
• Rheumatoid Arthritis and Risk of CVD and Total Mortality
• Epidemiology of Heterogeneity in type 2 Diabetes
• Epidemiology of Putative Genuine Genetic Variants: The WHI


Co-Principal Investigator


• Dynamic of Health, Aging and Body Composition (1996-2004) NIA
• Ginkgo Biloba Prevention Trial in Older Individuals (1999-2005) NCCAM


Co-Investigator


• CDC Prevention Research Center (Center for Healthy Aging) (2005-2009)
• Osteoporotic Fractures in Men (2006-2012)
• Epidemiology of CHD of Men Aged 40+ in US, Hawaii and Japan (2008-2012)
• Cardiovascular Disease in HIV Infected and Uninfected Veterans (2009-2011)
• Predictors of Alzheimers Disease in Mild Cognitive Impairment (2008-2012)

Education & Training

• Hamilton College - B.A., 1955
• George Washington University - M.D. Medicine, 1959
• Johns Hopkins University - M.P.H. Public Health, 1964
• Johns Hopkins University - Dr.P.H. Public Health, 1966

Recent Publications

Crandall CJ, Aragaki AK, Chlebowski RT, McTiernan A, Anderson G, Hendrix SL, Cochrane BB, Kuller LH, Cauley JA. New-onset breast tenderness after initiation of estrogen plus progestin therapy and breast cancer risk. Arch Intern Med 2009;169:1684-1691.

Kuller LH. Weight loss and reduction of blood pressure and hypertension (Editorial Commentary). Hypertension 2009;54:700-701.

Tindle HA, Chang Y-F, Kuller LH, Manson JE, Robinson JG, Rosal MC, Siegle GJ, Matthews KA. Optimism, cynical hostility, and incident coronary heart disease and mortality in the Women's Health Initiative. Circulation 2009;120:656-662.

Okamura T, Sekikawa A, Kadowaki T, El-Saed A, Abbott RD, Curb JD, Edmundowicz D, Nakamura Y, Murata K, Kashiwagi A, Sutton-Tyrrell K, Evans RW, Zmuda JM, Maegawa H, Hozawa A, Mitsunami K-I, Nishio Y, Miljkovic-Gacic I, Horie M, Miyamatsu N, Murakami Y, Kuller LH, Ueshima H. Cholesteryl ester transfer protein, coronary calcium, and intima-media thickness of the carotid artery in middle-age Japanese men. Am J Cardiol 009;104:818-822.

Pratt SR, Kuller L, Talbott EO, McHugh-Pemu K, Buhari AM, Xu X. Prevalence of hearing loss in black and white elders: results of the Cardiovascular Health Study. J Speech Lang Hear Res 2009;52:973-89.

Khachaturian, Convener & Co-Chair, Cami j, Co-Chair, Andrieu S, Avila J, Rovira MB, Breteler M, Froelich L, Gauthier S, Gomez-Isla T, Khachaturian AS, Kuller LH, Larson EB, Lopez OL, Martinez-Lage J, Petersen RC, Schellenberg GD, Sunyer J, Vellas B, Bain LJ, reporter. Creating a transatlantic research enterprise for preventing Alzheimer's disease. Alzheimers Dement 2009;5:361-366.

Azuma K, Kadowaki T, Centinel C, Kadota A, El-Saed A, Kadowaki S, Edmundowicz D, NBishio Y, Sutton-Tyrrell K, Okamura T, Evans RW, Takamiya T, Ueshima H, Curb JD, Abbott RD, Kuller LH, Kelley DE, Sekikawa A, for the ERA JUMP study group. Metabolism 2009;58:1200-1207.

Sink KM, Leng X, Williamson J, Kritchevsky SB, Yaffe K, Yasar S, Atkinson H, Robbins M, Psaty B, Goff DC Jr. Angiotensin-converting enzyme inhibitors and cognitive decline in older adults with hypertension. Results from the Cardiovascular Health Study. Arch Intern Med 2009;169:1195-1202

Prentice RL, Manson JE, Langer RD, Anderson GL, Pettinger M, Jackson RD, Johnson KC, Kuller LH, Lane DS, Wactawski-Wende J, Brzyski R, Allison M, Ockene J, Sarto G, Rossouw JE. Benefits and risks of postmenopausal hormone therapy when it is initiated soon after menopause. Am J Epidemiol 2009;170:12-23.

The Emerging Risk Factors Collaboration. Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality. JAMA 2009;302:41-423.

Soreca I, Rosano C, Jennings JR, Sheu LK, Kuller LH, Matthews KA, Aizenstein HJ, Gianaros PJ. Gain in adiposity across 15 years is associated with reduced gray matter volume in healthy women. Psychosom Med 2009;71:485-490.

Barnes DE, Covinsky KE, Whitmer RA, Kuller LH, Lopez OL, Yaffe K. Predicting risk of dementia in older adults. The late-life dementia risk index. Neurology 2009;73:173-179.

Greco CM, Kao AH, Sattar A, Danchenko N, Maksimowicz-McKinnon KM, Edmundowicz D, Sutton-Tyrrell K, Tracy RP, Kuller LH, Manzi S. Association between depression and coronary artery calcification in women with systemic lupus erythematosus. Rheumatology 2009;48:576-81.

Okobia MN, Bunker CH, Garte SJ, Zmuda JM, Ezeome ER, Anyanwu SNC, Uche EEO, Osime U, Ojukwu J, Kuller LH, Ferrell RE, Taioli E. Cytochrome P450 IBI Val432Leu polymorphism and breast cancer risk in Nigerian women: A case control study. Infect Agent Cancer 2009;4(Suppl 1):S12-19.

Carmichael OT, Lopez O, Becker JT, Kuller L. Trajectories of brain loss in aging and the development of cognitive impairment. Neurology. 2009;72(8):771 (Comment on Carlson et al, Neurology. 2009 Mar 11;70(11):828-33.)

Fitzpatrick AL, Kuller LH, Lopez OL, Diehr P, O'Meara ES, Longstreth WT Jr, Luchsinger JA. Midlife and late-life obesity and the risk of dementia. Cardiovascular Health Study. Arch Neurol 2009;66:336-42.