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Faculty Bio - Jane A. Cauley, DrPH
Professor
Department of Epidemiology
A524 Crabtree Hall
University of Pittsburgh
Pittsburgh, PA 15261
Voice: 412-624-0218
E-mail: JCauley@edc.pitt.edu






Research Interests
  • Epidemiology of Osteoporotic Fractures and Falls
  • Epidemiology of Aging, including Women's health issues, and heart disease
  • Epidemiology of Sex Hormones and Their Relationship to Chronic Disease
  • Epidemiology of Breast Cancer
  • Inflammation, Vitamin D and Fractures/ Osteoporosis
  • Ethnic/Racial Differences in Fracture
Research Support
    Principal Investigator

    • Study of Osteoporotic Fractures (SOF) (1986- present) NIH
    • Osteoporotic Fractures In Men, (MrOS) (1999- present) NIH
    • National Children’s Study(2007-12) NICHD
    • Postmenopausal Evaluation and Risk-reduction with Lasofoxifene (PEARL) (2001-09) Pfizer
    • Safety and Efficacy of Zoledronic Acid in Osteoporosis, (HORIZON) (2002-12) Novartis
    • Outcomes of Sleep Disorders in Older Men (MrOS Sleep) (2003-present) NHLBI
    • Health Decline in Aged Caregivers: An Epidemiological Study (2005-10) Boston University
    • Estradiol, Cytokines & Bone Turnover- Effects on Fracture (2005-10) NIAMS
    • Changes in Sleep and Cognition in Older Women (SOF Sleep) (2006-11) Cal Pac Med Center
    • Biochemical Antecedents of Fracture in Minority Women (2007-10) NHLBI
    • Hip Strength Across the Menopausal Transition (SWAN Hip) (2007-12) NIA
    • Pitt-MCRC for Rheumatic and Musculoskeletal Diseases (2007-12) NIAMS
    • Testosterone Trial (T Trial) (2009-15) University of Pennsylvania
    • Vitamin D, Falls and Fractures and Function in Community-dwelling Older Adults (2008-12) Wake Forest University

    Co-Principal Investigator

    • Bone Strength Phenotypes in Men: Genes and Environment (2004-10) NIAMS
    • Study of Women’s Health Across the Nation (SWAN) (2004-09) NIAMS
    • Peripheral Nerve Function Decline in an Aged Cohort (2007-11) NIA
Education & Training
  • Boston College - B.S.N. Nursing, 1975
  • University of Pittsburgh - M.P.H. Epidemiology/Public Health Nursing, 1980
  • University of Pittsburgh - Dr.P.H. Epidemiology, 1983
Selected Publications

Cauley JA, Palermo L, Vogt M, Ensrud KE, Ewing S, Hochberg M, Nevitt MC, Black DM. Prevalent Vertebral Fractures in Black Women and White Women. J Bone Miner Res. 2008;23(9):1458-67.

Cauley JA, Ensrud KE. Considering competing risks…not all black and white. Arch Intern Med 2008; 168(8):793-94.

Cauley JA, Wampler N, Barnhart J, Wu L, Allison M, Chen Z, Hendrix S, Robbins JA, Jackson R. Incidence of fractures compared to cardiovascular disease and breast cancer: WHI. Osteoporos Int. 2008;19(12):1717-23.

Hill DD, Cauley JA, Sheu Y, Bunker CH, Patrick AL, Baker CE, Beckles GLA, Wheeler VW, Zmuda JM. Correlates of bone mineral density in males of African ancestry: The Tobago Bone Health Study. Osteoporos Int. 2008 19:227-34.*

Goldman SE, Hall M, Boudreau R, Matthews KA, Cauley JA, Ancoli-Israel S, Stone KL, Rubin SM, Satterfield S, Simonsick EM, Newman AB. Association between nighttime sleep and napping in older adults. Sleep 2008;32:1-5.

Khalil N, Cauley JA, Wilson JW, Talbott EO, Morrow L, Hochberg MC, Hillier TA, Muldoon SB, Cummings SR. The relationship of blood lead levels to incident non-spine fractures and falls in older women: The Study of Osteoporotic Fractures.J Bone Miner Res 2008:23:1417-25. *

Ix JH, Wassel-Fyr C, Kanaya A, Vittinghoff E, Johnson KC, Koster A, Cauley JA, Harris TB, Cummings SR, Shlipak MG for the Health ABC Study. Fetuin A and incident diabetes mellitus in older persons: The Health ABC Study. JAMA 2008;300(2):182-188.

Stone KL, Ancoli-Israel S, Blackwell T, Ensrud KE, Cauley JA, Redline S, Hillier TA, Schneider J, Claman D, Cummings SR. Actigraphy-measured sleep characteristics and risk of falls in older women. Arch Intern Med. 2008;168(16):1768-75.

Orwoll E, Nielson CM, Marshall LM, Lambert L, Holton KF, Hoffman AR, Barrett-Connor E, Shikany JM, Dam T, Cauley JA; for the Osteoporotic Fractures in Men (MrOS) Study Group. Vitamin D deficiency in older men. J Clin Endocrinol Metab. 2009;94(4):1214-22.

Reeves KW, Ness RB, Stone RA, Weissfeld JL, Vogel VG, Powers RW, Modugno F, Cauley JA. Vascular endothelial growth factor and breast cancer risk. Cancer Causes Control. 2009 20:375-86.*

Cauley JA, Lui LY, Genant HK, Salamone L, Browner W, Fink HA, Cohen P, Hillier T, Bauer DC, Cummings SR for the Study of Osteoporotic Fractures Research Group. Risk factors for severity and type of the hip fracture. J Bone Miner Res. 2009 May;24(5):943-55.

Cauley JA, Parimi N, Ensrud KE, Bauer DC, Cawthon, Cummings SR, Hoffman AR, Shikany, Barrett-Connor E, Orwoll E for the Osteoporotic Fractures in Men (MrOS) Research Group. Serum 25 HydroxyVitamin D and the Risk of Hip and Non-spine Fractures in Older Men. J Bone Miner Res. 2009 June, In Press.

Farhat GH, Taioli E, Cauley JA, Zmuda JM, Orwoll E, Bauer DC, et al. The association of bone mineral density with prostate cancer risk in the Osteoporotic Fractures in Men (MrOS) Study. Cancer Epidemiol Biomarkers Prev, 2009;18:148-154.*

Ness RB, Albano JD, McTiernan, Cauley JA. Influence of estrogen plus testosterone supplementation of breast cancer. Arch Intern Med, 2009;169:41-6.

Yerges LM, Zhang Y, Cauley JA, Kammerer CM, Nestlerode CS, Wheeler VW, et al. Functional characterization of genetic variation in the Frizzled 1 (FXD1) promoter and assocation with bone phenotypes: more to the LRP5 story? J Bone Miner Res, 2009;24:87-96.

Brunner R, Dunbar-Jacob J, LeBoff MS, Granek I, Bowen D, Snetselaar LG, Shumaker SA, Ockene J, Rosal M, Wactawski-Wende J, Cauley J, Cochrane B, Tinker L, Jackson R, Wang CY, Wu L. Predictors of adherence in the Women's Health Initiative Calcium and Vitamin D Trial. Behav Med, 2009:34(4):145-55.

Khalil N, Morrow LA, Needleman H, Talbott EO, Wilson JW, Cauley JA. Association of cumulative lead and neurocognitive function in an occupational cohort. Neuropsychology 2009 Jan;23(1):10-9.*

Stone KL, Ewing SK, Ancoli-Israel S, Ensrud KE, Redline S, Bauer DC, Cauley JA, Hillier TA, Cummings SR. Self-reported sleep and nap habits and risk of mortality in a large cohort of older women. J Am Geriatr Soc. 2009 Apr;57(4):604-11.

Ensrud KE, Ewing SK, Cawthon PM, Fink HA, Taylor B, Cauley JA, Dam TT, Marshall LM, Orwoll ES, Cummings SR for the Osteoporotic Fractures in Men (MrOS) Research Group. A comparison of frailty indexes for the prediction of falls, disability, fractures and mortality in older men. J Am Geriatr Soc., 2009;57(3):492-8.

Reeves KW, Ness RB, Stone RA, Weissfeld JL, Vogel VG, Powers RW, Modugno F, Cauley JA. Vascular endothelial growth factor and breast cancer risk. Cancer Causes Control. 2009 20:375-86.*

Zmuda JM, Yerges LM, Kammerer CM, Cauley JA, Wang X, Nestlerode CS, Wheeler VW, Patrick AL, Bunker CH, Moffett SP, Ferrell RE. Association analysis of WNT10B with bone mass and structure among individuals of African ancestry. J Bone Miner Res. 2009 Mar;24(3):437-47.

Ix JH, Wassel CL, Bauer DC, Toroian D, Tylavsky FA, Cauley JA, Harris TB, Price PA, Cummings SR, Shlipak MG; Health ABC Study. Fetuin-A and BMD in older persons: the Health Aging and Body Composition (Health ABC) study. J Bone Miner Res. 2009 Mar;24(3):514-21.

Glover SJ, Gall M, Schoenborn-Kellenberger O, Wagener M, Garnero P, Boonen S, Cauley JA, Black DM, Delmas PD, Eastell R. Establishing a reference interval for bone turnover markers in 637 healthy, young, pre-menopausal women from UK, France, Belgium and the USA. J Bone Miner Res. 2009;24(3):389-97.

Orwoll ES, Marshall LM, Nielson CM, Cummings SR, Lapidus JA, Cauley JA, Ensrud KE, Lane N, Hoffmann PR, Kopperdahl DL, Keaveny TM. Finite element analysis of the proximal femur and hip fracture risk in older men. J Bone Miner Res. 2009 Mar;24(3):475-83.

Yaffe K, Lindquist K, Sen S, Cauley J, Ferrell R, Penninx B, Harris T, Li R, Cummings SR; for the Health ABC Study. Estrogen receptor genotype and risk of cognitive impairment in elders: Findings from the Health ABC study. Neurobiol Aging. 2009;30(4):607-14.

Sheu Y, Cauley JA, Wheeler VW, Patrick AL, Bunker CH, Kammerer CM, Zmuda JM.Natural history and correlates of hip bone mineral density loss with aging in men of African Ancestry: The Tobago Bone Health Study. J Bone Miner Res. 2009 Mar 3. [Epub ahead of print].*

Beck TJ, Petit M, Wu G, LeBoff MS, Cauley JA. Does obesity really make the femur stronger? BMD, geometry and fracture incidence in the WHI-OS. J Bone Miner Res. 2009 Mar 17. [Epub ahead of print].

Khalil N, Cauley JA, Wilson JW, Talbott EO, Morrow L, Hochberg MC, Hillier TA, Muldoon SB, Cummings SR. Associations of blood lead and mortality. Environmental Health Journal. 2009 38(1):375-86.* Kuipers A, Zhang Y, Cauley JA, Nestlerode CS, Chu Y, Bunker CH, Patrick AL, Wheeler VW, Hoffman AR, Orwoll ES, Zmuda JM. Association of a high mobility group gene (HMGA2) variant with bone mineral density. Bone. 2009 Apr 17. [Epub ahead of print].

Schwarz E, Ray RM, Stuebe AM, Allison MA, Ness RB, Freiberg MS, Cauley JA. Duration of lactation and risk factors for maternal cardiovascular disease. Obstet Gynecol. 2009 May;113(5):974-982.

LaCroix AZ, Kotchen J, Anderson G, Brzyski R, Cauley JA, Cummings SR, Gass M, Johnson KC, Ko M, Larson J, Manson JE, Stefanick ML, Wactawski-Wende J. Calcium plus vitamin D supplementation and mortality in postmenopausal women: the Women's Health Initiative calcium-vitamin D randomized controlled trial. J Gerontol A Biol Sci Med Sci. 2009 May;64(5):559-67.

Cawthon PM, Ewing SK, McCulloch CD, Ensrud KE, Cauley JA, Cummings SR, Orwoll ES. Loss of hip bone mineral density in older men: MrOS. J Bone Miner Res. 2009 May 6. [Epub ahead of print].

Cauley JA, Lacroix AZ, Robbins JA, Larson J, Wallace R, Wactawski-Wende J, Chen Z, Bauer DC, Cummings SR, Jackson R. Baseline serum estradiol and fracture reduction during treatment with hormone therapy: the Women’s Health Initiative Randomized Trial. Osteoporos Int. 2009 May 13. [Epub ahead of print].

Fredman L, Doros G, Ensrud KE, Hochberg, M, Cauley JA. Caregiving Intensity and Change in Physical Functioning Over a 2-Year Period: Results of the Caregiver-Study of Osteoporotic Fractures. Am J Epidemiol. 2009 May 14. [Epub ahead of print].

Ensrud KE, Taylor BC, Paudel ML, Cauley JA, Cawthon PM, Cummings SR, Fink HA, Barrett-Connor E, Zmuda JM, Shikany JM, Orwoll ES; for the Osteoporotic Fractures in Men (MrOS) Study Group. Serum 25-hydroxyvitamin D Levels and Rate of Hip Bone Loss in Older Men. J Clin Endocrinol Metab. 2009 May 19. [Epub ahead of print].

Miljkovic I, Cauley JA, Petit MA, Ensrud KE, Strotmeyer E, Sheu Y, Gordon CL, Goodpaster BH, Bunker CH, Patrick AL, Wheeler VW, Kuller LH, Faulkner KA, Zmuda JM; for the Osteoporotic Fractures in Men (MrOS) Research Group and the Tobago Health Studies Research Group. Greater Adipose Tissue Infiltration in Skeletal Muscle among Older Men of African Ancestry. J Clin Endocrinol Metab. 2009 May 19. [Epub ahead of print].

Sheu Y, Cauley JA, Bunker CH, Wheeler VW, Patrick AL, Gordon CL, Kammerer CM, Zmuda JM. Correlates of Trabecular and Cortical Volumetric Bone Mineral Density in Men of African Ancestry. J Bone Miner Res. 2009 May 19. [Epub ahead of print].*

Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM; for the MrOS Research Group. A High-Density Association Study of 383 Candidate Genes for Volumetric Bone Density at the Femoral Neck and Lumbar Spine among Older Men. J Bone Miner Res. 2009 May 19. [Epub ahead of print].

Bauer DC, Garnero P, Harrison S, Cauley J, Eastell R, Ensrud K, Orwoll E; For the Osteoporotic Fractures in Men (MrOS) Research Group. Biochemical Markers of Bone Turnover, Hip Bone Loss and Fracture in Older Men: The MrOS Study. J Bone Miner Res. 2009 May 19. [Epub ahead of print].

Reiner A, LaCroix A, Gray SL, Aragaki A, Kooperberg C, Woods NF, Cochrane B, Cauley JA, Wactawski-Wende J. Inflammation and thrombosis biomarkers and incident frailty in postemenopausal women. Am J Med, In press.

Cauley JA, Parimi N, Ensrud KE, Bauer DC, Cawthon, Cummings SR, Hoffman AR, Shikany, Barrett-Connor E, Orwoll E for the Osteoporotic Fractures in Men (MrOS) Research Group. Serum 25 HydroxyVitamin D and the Risk of Hip and Non-spine Fractures in Older Men. J Bone Miner Res. 2009 June, In Press.

Lang TF, Cummings SR, Harris T, Bauer D, Tylavsky FA, Cauley JA, Computed tomography measurements of thigh muscle cross-sectional area and attenuation coefficient predict hip fracture. J Bone Miner Res. 2009 June, In Press.

Crandall CJ, Aragaki A, McTiernan A, Cochrane B, anderson G, Hendrix S, Cauley JA, Kuller L, Langer R, Chlebowski R. New-onset breast tenderness after initiation of estorgen plus progestin therapy and breast cancer risk. Arch of Int Med, 2009 June, Accepted.

Barrett-Connor E, Nielson CM, Orwoll E, Bauer DC, Cauley JA for the Osteoporotic Fracture in Men MrOS Group. The epidemiology of rib fractures in older men: the Osteoporotic Fractures in Men (MrOS) Study. JAMA, submitted April 2009.

Grady D, Cauley JA, Stock JL, cos DA, Mitlak BH, Song Jingli, Cummings SR. Effect of ralixifene on all-cause mortality. Obstet and Gynecol, Submitted April 2009.